In their animal experiments, the researchers observed that this drug administration could reverse the consequences of the overdose 96 % of some time.The system also includes a smaller reservoir that will have around ten milligrams of naloxone. When an overdose is detected, it triggers a pump that ejects the naloxone, which can be produced inside of
Omtrent seven-nine % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit by means of CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.
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